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A review by Cochrane concluded that the vaccine was useful for preventing shingles for at least three years.[7] This equates to about 50% relative risk reduction. The vaccine reduced rates of persistent, severe pain after shingles by 66% in people who contracted shingles despite vaccination.[51] Vaccine efficacy was maintained through four years of follow-up.[51] It has been recommended that people with primary or acquired immunodeficiency should not receive the live vaccine.[51]

Antiviral therapy
The standard, effective and specific treatment for genital herpes is oral antiviral therapy, which is usually in tablet form. Antiviral drugs work by stopping HSV from replicating in the body. The antiviral drug only works in body cells where the herpes virus is present, therefore making the drug safe and free from side effects. The treatment only works while you are taking the drug and cannot prevent future outbreaks once you stop taking it.

While condoms are effective in preventing the spread of some STDs, they are not perfect. Condoms are better at protecting against gonorrhea, chlamydia, HIV, and trichomoniasis. But they offer less protection against herpes, syphilis, and genital warts. These infections can spread through contact with skin lesions that are not covered by a condom. Finally, condoms offer virtually no protection against crabs and scabies.

These drugs may stop viral replication in the skin but do not eliminate HSV from the body or prevent later outbreaks (HSV reactivation). These drugs are used more frequently with HSV-2 infections. Most investigators suggest consulting an infectious-disease expert when HSV-infected people need hospitalization. Research findings suggest laser treatments may speed healing and lengthen the time before any sores reappear.

One of the most commonly sexually transmitted diseases for both men and women is the herpes simplex virus (HSV). Either through intercourse or oral sex, people can pass either the HSV type 1 through the mouth or HSV 2 through intercourse.

13. Freeman EE, Weiss HA, Glynn JR, Cross PL, Whitworth JA, Hayes RJ. Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. AIDS, 2006. 20(1): 73–83.

Genital herpes is not only transmitted during vaginal and anal intercourse. It also is possible to get genital herpes in the mouth, tongue, lips and other parts of the body. However, this is quite rare and it usually occurs when blisters are present during intercourse.

Jump up ^ Jocelyn A. Lieb; Stacey Brisman; Sara Herman; Jennifer MacGregor; Marc E. Grossman (2008). “Linear erosive Herpes Simplex Virus infection in immunocompromised patients: the “Knife-Cut Sign””. Clin Infect Dis. 47 (11): 1440–41. doi:10.1086/592976. PMID 18937574.

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^ Jump up to: a b Steiner I, Kennedy PG, Pachner AR (2007). “The neurotropic herpes viruses: herpes simplex and varicella-zoster”. Lancet Neurol. 6 (11): 1015–28. doi:10.1016/S1474-4422(07)70267-3. PMID 17945155.

Chlamydia in women is a common cause of infertility. When a woman gets infected, the infection affects the cervix first (the cervix is the opening of the uterus). If the condition is not treated, the chlamydia bacteria can spread to the fallopian tubes and ovaries. It is believed, that chlamydia causes damage to the hairs lining the fallopian tubes, which help guide the egg from the ovaries to the womb. This damage leads to scarring, causing the tubes to become blocked. The blockage of the fallopian tubes can result in permanent infertility.

Concern has been expressed that routine childhood varicella vaccination, introduced in the United States in 1996, could thereby lead to an increase in herpes zoster incidence by reducing opportunities for exposure to varicella,” researchers led by Dr.

Until the 1940s the disease was considered benign, and serious complications were thought to be very rare.[92] However, by 1942, it was recognized that shingles was a more serious disease in adults than in children, and that it increased in frequency with advancing age. Further studies during the 1950s on immunosuppressed individuals showed that the disease was not as benign as once thought, and the search for various therapeutic and preventive measures began.[93] By the mid-1960s, several studies identified the gradual reduction in cellular immunity in old age, observing that in a cohort of 1,000 people who lived to the age of 85, approximately 500 (i.e., 50%) would have at least one attack of shingles, and 10 (i.e., 1%) would have at least two attacks.[94]

Hepatitis B is a virus that spreads through contact with body fluids and blood, so it can be transmitted through sexual intercourse. Hepatitis B infection is also possible through sharing of needles, razors, and toothbrushes. Babies can become infected at birth from an infected mother. It’s possible to go for years without symptoms of the infection.

It’s important to tell your obstetrician that you or a partner have had genital herpes, so that they can monitor you for symptoms and manage your pregnancy safely. There is a risk you can pass the virus on to your baby if you have a vaginal delivery during a first attack of genital herpes. If this happens you may be recommended to have a caesarean delivery.

Studies of couples where one partner has genital HSV-2 show transmission rates of between 5-20% per year, women with no exposure to HSV-1 having the highest risk (20%) and men with previous HSV-1 infection having the lowest risk (5%). Prior HSV-1 infection may give some cross-immunity to HSV-2 infection.

Although it is not lethal, the herpes simplex virus can also cause serious complications in patients who have HIV. HIV affects your body’s immune system, which can make it difficult to treat herpes outbreaks effectively. HIV patients often need a higher dose of antiviral treatment to control herpes.

It’s very important that you tell your doctor that you have genital herpes if you’re pregnant. They will take precautions to prevent the virus from being transmitted to your baby during delivery, with one likely method being that your baby would be delivered via cesarean rather than routine vaginal delivery.

Early symptoms and signs of genital herpes tend to develop within 3 to 7 days of skin-to-skin contact with an infected person. This 3 to 7 day period is known as the incubation period. Genital herpes infections look like a rash composed of small blisters or ulcers (round areas of broken skin) on the genitals. Each blister or ulcer is typically only 1 to 3 millimeters (1/32 inch to 1/8th inch) in size, and the blisters or ulcers tend to be grouped into “crops.” Usually the blisters form first, then soon open to form ulcers. Herpes infections may be painless or slightly tender. In some people, however, the blisters or ulcers can be very tender and painful.

Oral herpes is a viral infection mainly of the mouth area and lips caused by a specific type of the herpes simplex virus. Oral herpes is also termed HSV-1, type 1 herpes simplex virus, or herpes labialis. The virus causes painful sores on the upper and lower lips, gums, tongue, roof of the mouth, inside the cheeks or nose, and sometimes on the face, chin, and neck. Infrequently, it may cause genital lesions. It also can cause symptoms such as swollen lymph nodes, fever, and muscle aches. People commonly refer to the infection as “cold sores.”

Infection with HSV-2 in people living with HIV (and other immunocompromised individuals) often has a more severe presentation and more frequent recurrences. In advanced HIV disease, HSV-2 can lead to more serious, but rare, complications such as meningoencephalitis, esophagitis, hepatitis, pneumonitis, retinal necrosis, or disseminated infection.

Jump up ^ Schmader K, George LK, Burchett BM, Pieper CF (1998). “Racial and psychosocial risk factors for herpes zoster in the elderly”. J. Infect. Dis. 178 (Suppl 1): S67–S70. doi:10.1086/514254. PMID 9852978.

The sexually transmitted disease genital herpes is associated primarily with HSV-2. The virus is highly contagious and may be transmitted by individuals who are lifelong carriers but who remain asymptomatic (and may not even know they are infected). Infections are most often acquired through direct genital contact. Sexual practices involving oral-genital contact may be responsible for some crossover infections of HSV-1 to the genital area or of HSV-2 to the mouth and lips, while other crossover infections may be the result of self-infection through hand-genital-mouth contact.

People should not have genital, oral or anal sex while sores or blisters are present. However, it is important to remember that it is possible to transmit infection even if there are no obvious blisters, sores or other symptoms.

Stage 1 — Primary infection: The virus enters the skin or mucous membrane, usually through small cracks or breaks, and then reproduces. During this stage, oral sores, blisters, and other symptoms, such as fever, may develop.

Antiviral treatment very early in the course of the disease may decrease the length of recurrences. However, there is no satisfactory treatment for HSV-1 infection; as long as the virus remains in some cells in a latent form, antiviral drugs cannot rid the body of infection. The development of agents capable of preventing HSV-1 production of microRNAs is an area of great scientific interest. Such agents would cause the virus to become active, rendering it susceptible to existing antiviral agents that could then cure infection.

Your doctor will prescribe an antiviral medicine. These pills can help you feel better and shorten an outbreak. In the meantime, don’t kiss or have any kind of sex with other people. Even if you don’t have symptoms, you can still spread the disease.

The consistent and correct use of condoms can help reduce the risk of spreading genital herpes. However, condoms only provide partial protection, as HSV can be found in areas not covered by a condom. Medical male circumcision can provide men life-long partial protection against HSV-2, in addition to HIV and human papillomavirus (HPV).

A genital rash and mild itching usually are the earliest signs of infection. Eventually vesicles on the surface of the skin form, and then enlarge, break open, and ulcerate. The lesions are painful, especially during coitus, and can cause intense itching, and, if the urethra is involved, painful urination. The disease affects both sexes. In the male, vesicles are found principally on the glans penis, shaft of the penis, and prepuce, and may extend to the scrotum and inner thighs. In the female, vesicular eruptions usually involve the vulva, vagina, and cervix, and may extend to the perineum, inner thighs, and buttocks. Lesions of the cervix can vary from small superficial ulcers with diffuse inflammation to a single, large, necrotic ulcer. Other symptoms include malaise, fever, and anorexia. There also can be involvement of neural structures and the manifestation of neurologic symptoms. The characteristic lesions usually last from one to three weeks in either the initial stage or during periodic outbreaks.

Treatment is symptomatic and is aimed at relieving the pain and itching of the blisters. Local applications of calamine lotion or other lotions to dry the blisters may help. Herpes zoster is a very exhausting disease, especially for elderly people, because the constant itching and pain are difficult to control, even with systemic analgesics in some cases.

Genital herpes is different for each person. The signs and symptoms may recur, off and on, for years. Some people experience numerous episodes each year. For many people, however, the outbreaks are less frequent as time passes.

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