“multivariate normal +urticaria definition medical”

4. Rockwell WJ. Reactions to molds in foods. In: Chiaramonte LT, Schneider AT, Lifshitz F, editors. Food allergy: a practical approach to diagnosis and management. New York: Marcel Dekker; 1988. pp. 153–70.
A food allergy attack can last for quite a while as the allergen remains within your system and this increases the severity of the reaction. Drink plenty of fluids such as fresh fruit and vegetable juices as this will help to get rid of the allergen and reduce the recovery period.
That said, no two people respond to stressful events in the same way either. What may be a source of emotional excitement for you may cause fear for a friend. For instance, you may love to skydive on your weekend while your best friend cringes even thinking about flying in an airplane. That’s because we all perceive and respond to stressors differently. Again, it’s the inappropriate responses that influence your health and may influence your allergy symptoms.
Hives — also known as urticaria (ur-tih-KAR-e-uh) — is a skin reaction that causes itchy welts, which can range in size from small spots to large blotches several inches in diameter. Hives can be triggered by exposure to certain foods, medications or other substances.
In many cases, mild hives won’t need treatment and will go away on their own. If a definite trigger is found, avoiding is part of the treatment. If the hives feel itchy, the doctor may recommend an antihistamine medicine to block the release of histamine in the bloodstream and prevent breakouts.
Certain foods or beverages, such as spoiled fish (scombroidosis), aged cheeses, or red wine, can contain histidine, which is closely related to histamine. These foods are often listed as causes of urticaria in the literature, but experimental evidence is scarce.
Hives caused by the radiocontrast dye, codeine, morphine, and aspirin are usually not triggered by the immune system, rather these drugs cause the direct release of histamine from specialized white blood cells called mast cells.
What we are referring to is allergens, or substances that cause the body to react in the form of an allergic reaction. This reaction can take many forms from fever, to swelling, stuffy nose, and depending on the severity of the allergy, possible even death. However, for this purpose of this article, we are going to focus on one of the most common reactions to allergens, and that is hives.
Jump up ^ Bito, Toshinori; Sawada, Yu; Tokura, Yoshiki (2012). “Pathogenesis of Cholinergic Urticaria in Relation to Sweating”. Allergology International. 61 (4): 539–44. doi:10.2332/allergolint.12-RAI-0485. PMID 23093795.
Eileen Bailey is a freelance health writer. She is the author of What Went Right: Reframe Your Thinking for a Happier Now, Idiot’s Guide to Adult ADHD, Idiot’s Guide to Cognitive Behavioral Therapy, Essential Guide to Overcoming Obsessive Love, and Essential Guide to Asperger’s Syndrome. She can be found on Twitter @eileenmbailey and on Facebook at eileenmbailey.
The most popular treatment for relief from hives is an over-the-counter medication that contains antihistamine. These drugs help fight against an attack of hives and counter the release of histamine from the skin cells that causes the rash. However, antihistamines tend to have side effects such as drowsiness, especially in children. If you prefer an alternative hives treatment, there are several home remedies for hives that are not only effective but safe as well. Do keep in mind that not all home remedies are subjected to scientific testing and results can therefore vary considerably. Some popular methods of home treatment for relief include:

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Patients who have angioedema involving the oropharynx or any involvement of the airway should receive epinephrine 0.3 mL of 1:1000 solution sc be admitted to the hospital. On discharge, patients should be supplied with and trained in the use of an auto-injectable epinephrine pen.
Another possible explanation for your stress hives is that due to your weakened immune system, your skin is reacting to irritants that it never had problems with before: cold, heat, soaps, shampoos, lotions, laundry detergents, certain fabrics, sunlight, etc. In fact, there are even doctors that specialize in stress hives, known as psychodermatologists. These specialists work with skin illnesses and stress, and strongly feel that emotions that have not been properly dealt with can induce a rash in patients and that these deep seated emotions are the major cause of chronic hives.
Clinical Context:  Hydroxychloroquine is the preferred antimalarial agent because of its low toxicity and high effectiveness profile. It is usually well tolerated if carefully monitored by the prescribing physician. Therapy is required for 4-8 weeks before evaluating effectiveness.
An allergy refers to a misguided reaction by our immune system in response to bodily contact with certain foreign substances. When these allergens come in contact with the body, it causes the immune system to develop an allergic reaction in people who are allergic to it. It is estimated that 50 million North Americans are affected by allergic conditions. The parts of the body that are prone to react to allergies include the eyes, nose, lungs, skin, and stomach. Common allergic disorders include hay fever, asthma, allergic eyes, allergic eczema, hives, and allergic shock.
Angioedema is a reaction similar to hives that affects deeper layers of your skin. It most commonly appears around your eyes, cheeks or lips. Angioedema and hives can occur separately or at the same time.
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NUV is diagnosed where a patient has the main symptoms of Urticarial Vasculitis combined with normal levels of C1q complements. NUV is generally the least severe form of Urticarial Vasculitis. It is less likely to be associated with any other symptoms.
That said, no two people respond to stressful events in the same way either. What may be a source of emotional excitement for you may cause fear for a friend. For instance, you may love to skydive on your weekend while your best friend cringes even thinking about flying in an airplane. That’s because we all perceive and respond to stressors differently. Again, it’s the inappropriate responses that influence your health and may influence your allergy symptoms.
Disclosure: Serve(d) as a speaker or a member of a speakers bureau for: Biogen/IDEC (Discussion of Drug reactions in relationship to an agent for Multiple Sclerosis)
Received income in an amount equal to or greater than $250 from: Abbvie; Lilly; Argenx; Amgen
Received honoraria from UpToDate for author/editor; Received honoraria from JAMA Dermatology for associate editor; Received royalty from Elsevier for book author/editor; Received dividends from trust accounts, but I do not control these accounts, and have directed our managers to divest pharmaceutical stocks as is fiscally prudent from Stock holdings in various trust accounts include some pharmaceutical companies and device makers for i inherited these trust accounts; for: Celgene; Pfizer; 3M; Johnson and Johnson; Merck; Abbott Laboratories; AbbVie; Procter and Gamble; Amgen.
As in other types of vasculitis, diagnosis will depend on the doctor recognising the pattern of symptoms and examination findings. Blood is commonly taken to test for raised levels of “C-reactive protein” (CRP) and “Erythrocyte Sedimentation Rate” (ESR) which indicate inflammation in the body. Skin and kidney biopsies may also be taken to confirm the diagnosis.
In general, if an allergic reaction causes hives or swelling, it is usually ingested (food, oral drug) or injected (drugs, stings). If an allergen can penetrate the skin locally, hives will develop at the site of exposure. For example, contact urticaria may occur following exposure to latex gloves if sufficient latex penetrates through the skin.
Urticaria is also known as ‘nettle rash’ or ‘hives’. This condition consists of wheals – spots or patches of raised red or white skin – each of which usually clears away in a few hours to be replaced by other fresh wheals. Urticaria is very common and affects one in five people at some point in their lives.  The more common type of urticaria rash (hives) lasts up to 24 hours, produces larger wheals and may not completely clear for several days.  It sometimes occurs together with swelling of various parts of the body (angioedema) – typically the face, hands and feet, although anywhere may be affected.
Chronic urticaria is defined as hives, typically occurring daily, for greater than 6 weeks duration. Chronic idiopathic urticaria, which has no discernable external cause, comprises the majority of cases of chronic urticaria. Over half of all cases of chronic idiopathic urticaria are thought to occur by an autoimmune mechanism, primarily autoantibodies against the high affinity immunoglobulin E (IgE) receptor (FcεRI). Chronic urticaria is hypothesized to occur because of a predilection in the patient to develop reactions to self. Supporting this hypothesis, a strong association has been found between chronic urticaria and additional autoimmune diseases, such as thyroid disease, rheumatoid arthritis, systemic lupus erythematosus, Sjögren’s syndrome, celiac disease and type 1 diabetes, among others. Herein, we review the associations between chronic urticaria, thyroid disease, and other autoimmune disorders, as well as the implications that these correlations hold for therapeutic intervention in chronic urticaria.
The symptoms of a stress rash include red bumps and swollen areas on your skin that seem to appear randomly. Quite often, they are incredibly itchy and can also have a prickly or burning sensation when touched. Don’t scratch them! Don’t be surprised if your stress rash appears on your face, neck and chest, as that is where I get mine. Others get them on their arms and legs. Stress hives can be as small as a pencil eraser or as BIG as a dinner plate! Often the smaller hives meld with the bigger hives to make one big messy outbreak that looks absolutely terrible. However, with the right over the counter medication, like OxyHives, you’ll be able to get rid of them in no time.
The main treatment of all forms of urticaria in adults and in children is with an oral second-generation antihistamine chosen from the list below. If the standard dose (eg 10 mg for cetirizine) is not effective, the dose can be increased up to fourfold (eg 40 mg cetirizine daily). They are stopped when the acute urticaria has settled down. There is not thought to be any benefit from adding a second antihistamine.
Your doctor will likely recommend you treat your symptoms with home remedies, such as over-the-counter antihistamines. If self-care steps don’t help, talk with your doctor about finding the prescription medication or combination of drugs that works best for you. Usually, an effective treatment can be found.

“urticaria hives +what causes chronic hives”

Acute urticaria may be, in a short time, associated with life-threatening angioedema and/or anaphylactic shock, although it usually presents as rapid-onset shock without urticaria or angioedema. (See Emergency Care and Complications.)
Hives are a common occurrence, affecting up to 25% of the population at least once in their lives. They can be short term, lasting only a few days to six weeks, but they can be chronic and last for months or years. Chronic hives can be especially frustrating for patients. They may or not be related to an allergy. In some cases the cause is never identified.
If Aspirin & Salicylate intolerance is suspected then all forms of Salicylate including toothpaste, muscle rubs and peppermints should also be avoided. Aspirin sensitive individuals tolerate the newer Cyclo-oxygenase-2 selective inhibitors or COX-2 anti-inflammatory (NSAI) medications such as Celecoxib and Meloxicam.
Aloe vera gel can also be applied over the affected area to reduce inflammation. Aloe vera gel is know to have a cooling effect and this will help provide relief, especially if you have the urge to scratch the area.
No. Seriously, stress is a mental state. And we treat mental problems with mind treatment, not with supplements. This advice, unfortunately, fails to find and explain the real cause of your stress problem.
In some people hives are caused by physical triggers, including cold (such as cold air, water or ice), heat, sunlight (solar), vibration, rubbing or scratching of the skin (dermatographism) and delayed pressure (such as after carrying heavy bags.  In other people, exercise (sweating), stress, alcohol, spicy food or coffee may cause symptoms.
The majority of stinging insects in the United States are from bees, yellow jackets, hornets, wasps, and fire ants. Severity of reactions to stings varies greatly. Avoidance and prompt treatment are essential. In selected cases, allergy injection therapy is highly effective.
Loratadine is commonly used to treat both acute (sudden) and chronic (long-term) urticaria (hives). It is considered safe to use long-term, but talk to your doctor to make sure you should continue after about six months.
In a November 2008 interview with leading Swedish newspaper Dagens Nyheter, Swedish rapper Petter announced that the Hives were working on a new version of his track “Repa skivan” for his upcoming album.[24]
An eruption of itching wheals, colloquially called hives, usually of systemic origin; may be due to a state of hypersensitivity to foods or drugs, foci of infection, physical agents (heat, cold, light, friction), or psychic stimuli.
An itchy skin eruption characterized by weals with pale interiors and well-defined red margins; usually the result of an allergic response to insect bites or food or drugs. – (Source – Diseases Database)
Getting to the bottom of what caused your hives is not easy and it’s possible that you may never know. However, it’s also likely that you can check many of these known causes off your list of potential triggers. Since most cases have no known cause, what is important is properly treating hives, which is typically done with done with antihistamines.

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Nonthrombocytopenic purpura: Cryofibrinogenemic purpura Drug-induced purpura Food-induced purpura IgA vasculitis Obstructive purpura Orthostatic purpura Purpura fulminans Purpura secondary to clotting disorders Purpuric agave dermatitis Pigmentary purpuric eruptions Solar purpura Traumatic purpura Waldenström hyperglobulinemic purpura Painful bruising syndrome
How do you get hives? Hives are not something you can “catch” from anyone. Rather, they are your body’s response to something it ingests or experiences. The cause of hives can be a certain food, drug, infection or stress. You might be surprised to learn that stress is one of the most common causes of acute hives, along with allergies and infectious causes. Hives can literally occur at any age and appear anywhere on the body. It is estimated that one in every five people will be affected by a hives outbreak at some point in his or her life. (2)
“So, on the flip side of this, we can ask, ‘How can psychological interventions bolster the immune system and relieve somatic symptoms?’ Buffet in 2003 showed improvement in urticarial wheals after subcutaneous injection with histamine when treated with hypnosis and relaxation techniques (Buffet M. Ann Dermatol Venereol. 2003;130(1):S145-S159),” she says.
Hives (AKA urticaria) is not contagious by any means. They are a skin disorder that results in red, sometimes itching patches of raised skin. The patches of skin can be small or large, and generally appear quite fast and disappear on their own within hours or days. They can be as small as a few millimeters and as large as inches, and can even join together to become large areas called plaques. When they join together all over your body, they are generally known as body hives. This form of rash is often quite itchy in nature and can burn. Learn more on our page title “Are Hives Contagious?”
Other medical conditions that can cause pruritus (usually without rash), such as diabetes mellitus, chronic renal insufficiency, primary biliary cirrhosis, or other nonurticarial dermatologic disorders
The natural history of urticarial vasculitis depends in part upon the blood complement levels. In cases where these are normal, the prognosis is generally good. In cases where the complements are low, the disease may be more severe. When urticarial vasculitis is related to a disease such as lupus or cancer, its prognosis is often governed by the prognosis of the underlying disease
“When people run, they can breathe better because epinephrine pours throughout the body,” says Berger, past president of the American College of Allergy and Immunology and author of Allergies and Asthma for Dummies.”Epinephrine is also triggered during stressful moments, which should add to better breathing — not worse!”
The symptoms of a stress rash include red bumps and swollen areas on your skin that seem to appear randomly. Quite often, they are incredibly itchy and can also have a prickly or burning sensation when touched. Don’t scratch them! Don’t be surprised if your stress rash appears on your face, neck and chest, as that is where I get mine. Others get them on their arms and legs. Stress hives can be as small as a pencil eraser or as BIG as a dinner plate! Often the smaller hives meld with the bigger hives to make one big messy outbreak that looks absolutely terrible. However, with the right over the counter medication, like OxyHives, you’ll be able to get rid of them in no time.
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An attack of hives can start off in part of the body and quickly move to another part. The rash has a tendency to appear and disappear with each individual outbreak not lasting for more than 24 hours at a time. An attack of hives can look quite alarming but it is also not uncommon for an outbreak to resolve completely by the time you see a doctor. No other skin condition has this characteristic of resolving by itself so rapidly. Before you visit your doctor, it may be wise to take a photograph of the outbreak at its worst so that he has something to base his diagnosis on. Symptoms of hives include:
Chronic idiopathic urticaria is the most common type of CU, comprising up to 90% of all cases of CU. It has been estimated that chronic idiopathic urticaria will affect between 0.6% to 5% of the population during their lifetime. Over half of all cases of chronic idiopathic urticaria are thought to be caused by an autoimmune mechanism. This is supported by the observation that 60% of patients with chronic idiopathic urticaria will have a wheal and flare reaction to intradermal autologous serum injections in the autologous serum skin test (ASST). Approximately 50% of patients with chronic idiopathic urticaria have IgG antibodies that are specific for the high affinity IgE receptor (FcεRI). These autoantibodies activate mast cells in the skin, circulating basophils, and the complement system.  Additional immunological abnormalities described to play a causative role in CU include IgG antibodies directed against IgE antibodies and the low affinity IgE receptor (FcεRII), antiendothelial antibodies, and complement C8 alpha-gamma (C8α-γ) deficiency.
Yang, H. Y., Sun, C. C., Wu, Y. C, & Wang, J. D. (2005, April). Stress, insomnia, and chronic idiopathic urticaria, a case-control study. Journal of the Formosan Medical Association,104(4):254-63. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/15909063
Winter is not exactly the most popular season, and with good reason for those who live with chronic hives: The cold can trigger a flare-up in some. Besides the weather, other cold-related triggers include chilly foods and swimming pools. For people who are allergic to the cold, full-body immersion in a swimming pool, in particular, can trigger a severe reaction that involves not just hives but allergic shock (anaphylaxis) and loss of consciousness.
The main treatment for acute urticaria in adults and in children is with an oral second-generation antihistamine chosen from the list below. If the standard dose (eg 10 mg for cetirizine) is not effective, the dose can be increased fourfold (eg 40 mg cetirizine daily). They are best taken continuously rather than on demand. They are stopped when the acute urticaria has settled down. There is not thought to be any benefit from adding a second antihistamine.
As far as the physical symptoms, you’ll see red bumps and swelling of the skin. They can develop anywhere on your body and be any size. Some people get breakouts as small as a penny, others get stress hives the size of a dinner plate or larger. Urticaria also has a tendency to spread around your body when you leave it untreated which is why you shouldn’t ignore it.
Hives causes can be avoided; sometimes only through trial and error. To do this, keep a journal of all the foods, medications and illnesses or activities that you or your child has prior to getting the hives. After a few cases of hives, your hives causes will be seen in the similarities between the cases. If you always get hives after being out in the direct sunlight for a few hours, your physical hives will then have a known allergen. In this way, you can avoid the allergen and be able to avoid the hives as well.
Patients may become sensitized to a very wide range of allergens and produce specific IgE (SIgE) against these substances. Subsequent contact with the relevant allergen, either directly on the skin or through mucous membranes, may result in urticaria.
Treatment depends on severity, specific disease manifestations, and a balance between efficacy and drug toxicity and/or side effects. Ideally, non-sedating antihistamines should be tried first, including increased doses as described above for physical urticarias controlled trails demonstrate efficacy at 4 the dose typically used for allergic rhinitis. The first generation antihistamines such as hydroxyzine or diphenydramine at 25-50 mg four times daily can be employed if the non-sedating, second-generation agents are insufficient. H2-receptor antagonists offer a little more global blockade of histamine receptors by inhibiting H2 receptors once H1 receptor blockage is maximal. There are 10-15% H2 receptors on venular endothelial cells. Leukotriene antagonists (montelukast, zafirlukast) can be tried in patients with severe symptoms but they may still not be satisfactorily controlled with the above-mentioned combinations. Alternate-day corticosteroids, eg, prednisone 10-25 mg every other day can be employed with gradual tapering at a rate of 2.5-5.0 mg every 2-3 weeks or 10-15 mg daily with taper of 1 mg/week. Another approach, and one that may be employed when use of corticosteroids is relatively contraindicated or when steroid side-effects prohibit their use, is cyclosporine. A typical dose range in adults is 200-300 mg/day, to be tapered to the lowest effective dose once a response is obtained. Monitoring of blood pressure and kidney function (urinalysis, BUN, creatinine) needs to be done on a regular basis.  The latest therapy is omalizumab supported by phase 1, 2, and three phase 3 trials.  It has the best efficacy to side effect profile and once approved for this indication (being reviewed currently) may supplant any use of sedating antihistamines once high-dose non-sedating agents fail.  H2 blockers and leukotriene antagonists may or may not be added next, but corticosteroids can be eliminated for chronic use, and cyclosporine reserved for omalizumab failures.
Low blood pressure, also referred to as hypotension, is blood pressure that is so low that it causes symptoms or signs due to the low flow of blood through the arteries and veins. Some of the symptoms of low blood pressure include:
Clinical examination may reveal urticaria, dermographism or angioedema or signs of a connective tissue disease or urticarial vasculitis, but it is often normal. Similarly, investigations are very often normal, particularly if there is a long history of urticaria, with no obvious triggering factors and if the patient is clinically well. Recent guidelines from the British Association of Dermatologists [44] and the British Society of Allergy and Clinical Immunology [45] suggest that investigations are not needed in all patients; however, individual patients may be reassured by a series of normal results. Depending on the clinical history, tests may include: full blood count (FBC) and differential, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), routine biochemistry, glucose, thyroid function, thyroid autoantibodies, anti-nuclear antibody (ANA), immunoglobulins and protein electrophoresis, complement C3 and C4, cryoglobulins, SIgE tests, serology for infections, stool sample for ova, cysts and parasites and urine analysis (for evidence of infection or renal vasculitis). Further investigations may, of course, be required if the initial screening tests are abnormal. For example, the presence of a normochromic, normocytic anaemia, lymphopaenia and strongly positive ANA would prompt further investigations for SLE.
Could you be allergic to your own sweat? Yes, says Dr. Anand. Although the cause of hives triggered by exercise is sometimes thought to be an increase of body heat, what actually triggers hives when you work out is sweat. Does that mean you should skip exercise if you have chronic hives? Not necessarily. Talk to your doctor if you suspect this may be one of your triggers — he or she may recommend taking a dose of antihistamine just before you exercise to help prevent a flare-up.
The presence of systemic symptoms could mean the urticarial rash is not ordinary urticaria,” he said, suggesting that vasculitis, Schitzler’s syndrome, adult-onset Still’s disease, an autoinflammatory syndrome, or urticarial dermatitis could be at play.
Rosacea is another common skin condition. Depending on the type, it often causes small, red, sometimes pus-filled bumps to form on the skin. The skin can thicken in these areas. The rash typically covers the cheeks, nose, and forehead. But it can involve other areas of the face. These bumps may appear for weeks to months before disappearing and appearing again at a later time.
Lancey RA, Schaefer OP, McCormick MJ. Coronary artery bypass grafting and aortic valve replacement with cold cardioplegia in a patient with cold-induced urticaria. Ann Allergy Asthma Immunol. 2004 Feb. 92(2):273-5. [Medline].
Urticarial vasculitis is a variant of cutaneous small vessel vasculitis. It is characterised by inflamed and reddened patches or weals on the skin that appear to resemble urticaria, but when the skin is examined closely under a microscope, a vasculitis is found (inflamed blood vessels).
The immediate symptoms of this type are treated with antihistamines, epinephrine and airway support. Taking antihistamines prior to exercise may be effective. Ketotifen is acknowledged to stabilise mast cells and prevent histamine release, and has been effective in treating this hives disorder. Avoiding exercise or foods that cause the mentioned symptoms is very important. In particular circumstances, tolerance can be brought on by regular exercise, but this must be under medical supervision.[citation needed]
Hives are very common and are not considered contagious. Although annoying, hives usually resolve on their own over a period of weeks and are rarely medically serious. Some hives may be caused by allergies to such things as foods, infections by different organisms, medications, food coloring, preservatives and insect stings or bites, and chemicals; but in the majority of cases, no specific cause is ever found. Although people may find it frustrating not to know what has caused their hives, maneuvers like changing diet, soap, detergent, and makeup are rarely helpful in preventing hives unless there is an excellent temporal relationship. Since hives most often are produced by an immune mechanism, the condition is not contagious. If an infectious disease were the cause of hives in a particular person then it is possible, but not likely, that an infected contact could develop hives.
Omalizumab, an anti-IgE antibody[9]. It is effective in 80% but requires monthly injections and relapse is common when it is stopped. The National Institute for Health and Care Excellence (NICE) recommends omalizumab as an add-on treatment for refractory severe chronic spontaneous urticaria[10].
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

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Many medications can cause hives, but only about 10% of hives are caused by medications. Hives will most often occur in the first 36 hours after starting the medication, but hives can occur even after taking a medicine for a long time. You can see that antibiotics are a common culprit.
Immunological: Some hives are caused by changes in the immune system. A typical scenario would be coming in contact with something that causes cells in the immune system to trigger the release of histamine from certain white blood cells called mast cells.
If the disease is very severe large doses of Methylprednisolone or Plasmapheresis (plasma exchange) may also be given. When the disease becomes quiet less toxic drugs are used to keep control and these include: Azathioprine, Methotrexate and Mycophenolate Mofetil usually in combination with low dose prednisolone.
Urticaria is a common condition – it is estimated that lifetime incidence of urticaria is approximately 15%, with females being affected more often than males. Both children and adults may develop urticaria, with the peak age of onset in adults being between 20 and 40 years. Urticaria is defined as ‘acute’ if it lasts for less than 6 weeks and ‘chronic’ if it lasts for more than 6 weeks. ‘Episodic’ urticaria, which occurs intermittently, but recurrently over months or years, is also recognized. Most urticarial reactions are acute and self-limiting; however, patients referred to allergy clinics usually have chronic urticaria or episodic urticaria. Histology shows oedema of the upper dermis, dilatation of blood vessels and lymphatics and a cellular infiltrate in the dermis. The nature of this cell infiltrate varies depending on the type of urticaria and the duration of the weal.
We classify Urticaria into Acute Urticaria when the rash duration is under 6 weeks and Chronic Urticaria when it persists for over 6 weeks. Physical Urticaria is due to an external physical trigger such as heat, cold, pressure or exercise (also called Inducible Urticaria). While Urticarial Vasculitis is a rare condition associated with underlying auto-immune connective tissue diseases which requires specialist referral.
Updated by: David L. Swanson, MD, Vice Chair of Medical Dermatology, Associate Professor of Dermatology, Mayo Medical School, Scottsdale, AZ. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Leukotrienes are released from mast cells along with histamine. The medications, montelukast and zafirlukast block leukotriene receptors and can be used as add on treatment or in isolation for patients with CU. It is important to note that these medications may be more beneficial for patients with NSAID induced CU.[42][43]
Hi I have found out I have this and been on many antihistamines to try and control it but I am now on fexafenidine and these don’t seem to work at all some days when I have a flare up I look like I…
The most common stressful events that were related to the occurrence of hives included the death of a family member, family conflicts, financial problems, sexual dysfunction, illness of a family member, problems in the workplace, and extramarital affairs. Even forms of good stress—such as getting married or engaged, and going on a vacation—can cause hives. The authors propose that the treatment of stress through relaxation techniques and stress management programs may be useful for the treatment of hives caused or worsened by stress.
Examination of the head should note any swelling of the face, lips, or tongue; scleral icterus; malar rash; tender and enlarged thyroid; lymphadenopathy; or dry eyes and dry mouth. The oropharynx should be inspected and the sinuses should be palpated and transilluminated for signs of occult infection (eg, sinus infection, tooth abscess).
Treatment depends on the extent of symptoms and organ involvement. When levels of complement are normal and there is no internal organ involvement or underlying disease, the symptoms may improve on their own or with minimal treatment. In this case, antihistamines or nonsteroidal drugs such as ibuprofen or naproxen may be helpful. For more severe cases, other drugs which affect the immune system may be needed, such as corticosteroids (prednisone, others), hydroxychloroquine, colchicine, dapsone; and chemotherapies like azathioprine or cyclophosphamide. Treatment may be intermittent, although it is not uncommon for patients to need treatment for several years.
Once a diagnosis of urticarial vasculitis is made, follow-up care depends on the patient’s complement levels. If complement level findings are normal, follow patients for symptoms and response to treatment. If complement level findings are low, follow patients for attendant complications related to the cause of their hypocomplementemia (see History).
Once the cause of the rash is identified, it may be possible to avoid situations that trigger it. However, in many cases it is difficult to stop sweating, particularly in warm climates and if exercising is part of a daily routine. Sometimes rapid cooling can prevent an attack. For most patients regular administration of an oral antihistamine such as cetirizine can be helpful in preventing the condition from arising. Beta-blockers such as propranolol have also been reported to be useful.
Unfortunately there are no known specific therapies for HUV. The regime of prescription steroids and other immunosuppressive drugs aims to dampen the body’s production of anti-C1q antibodies.[3] However, this again renders the individual immunocompromised.
A highly effective (but expensive) treatment recommended by the American FDA and British NICE guidelines for use as the preferred third line add-on treatment of Chronic Urticaria unresponsive to high dose antihistamines, includes subcutaneous injections of 300mg Omalizumab (Xolair) once a month for 6 months.  Recent studies on this monoclonal antibody (previously only used in asthma) show that once initial control is gained (after one month), the dose may be halved to maintain control for the 6 month induction period which can result in total remission of the Urticaria. However at least 40% will relapse after withdrawal of Omalizumab.  (Zuberbier et al, EAACI Guidelines urticaria, Allergy 69(7) 2014)
It was during the promotion of Veni Vidi Vicious and Your New Favourite Band that the Hives signed a record deal with Universal Music, reportedly worth $50 million. This led to a dispute between the Hives and Burning Heart, who claimed that the Hives were still contracted to them for one more album.
Hives are an unpleasant inflammatory skin condition that 20 percent of the population will experience at some point in time. Thankfully, hives typically are  not serious. With some simple natural remedies, you can calm a hives outbreak on yourself or your child quite quickly. Inexpensive, common household items like oatmeal, witch hazel and baking soda are really effective at calming the itching and redness that usually accompany hives. If your child experiences hives, you should make sure you aren’t using any harsh body care products on his or her skin. You should also avoid hot baths and tight-fitting clothes. I hope that you won’t experience hives anytime soon, but if you do, a natural hives treatment will really come in handy.
Clinical Context:  Indomethacin is the only NSAID reported effective in urticarial vasculitis. It is rapidly absorbed; metabolism occurs in the liver by demethylation, deacetylation, and glucuronide conjugation. Indomethacin inhibits prostaglandin synthesis.
Urticaria can vary from small bumps, or vary greatly in shape and size (from a pinhead to a frisbee).It may be localized to one part of the body or be widespread. It may start off localized only to spread to other areas of the body with time. Although they more commonly appear on the arms, legs and trunk, they can appear anywhere on the body.
When a person has had hives for over six weeks, they are termed chronic urticaria. Many experts believe that acute and chronic urticaria are no different except for duration. Some studies indicate that allergy is less likely to be an underlying factor in chronic urticaria. Since in 80 per cent of the cases of chronic urticaria the underlying cause is never found, not many conclusions can be made.
Inducible urticaria – sometimes called physical urticaria. This is a type of hives in which a rash appears when the skin is physically stimulated. The most common is called dermatographism (dermatographia) when a rash develops over areas of skin which are firmly stroked. In other cases, an urticarial rash is caused by heat, cold, emotion, exercise, or strong sunlight. See separate leaflet called Hives (Inducible Urticaria) for more details.
The majority of the time, a doctor will know that you have hives just by looking at your skin. To get to the root of your hives, a doctor also, hopefully, will  ask you about any recent life stressors, or exposure to possible or known allergens.  If a patient complains of itchiness, he or she will often recommend diphenhydramine. Common side effects of antihistamines include drowsiness, dizziness, dry mouth/nose/throat, upset stomach, increased appetite and weight gain, thickening of mucus, vision changes and feeling nervous, excited or irritable. (12)
The Hives’ official website was overhauled in the second week of August 2007, with a grungier, “emergency broadcast” layout. The new site revealed the album’s cover and the title of the first single, “Tick Tick Boom”, with a release date of August 14 in the United States and 8 October in the United Kingdom. The release dates for the new record, The Black and White Album, were 15 October in the UK on Polydor and November 13 in the US on A&M/Octone in 2007. It was mostly recorded in Oxford, Mississippi, Miami, and in their native Sweden.
Text: “Skin Conditions: Hives (Urticaria and Angioedema)”,- WebMD Medical Reference provided in collaboration with the Cleveland Clinic,”Understanding Hives- Treatment”, – WebMD Medical Reference, “Allergic Reaction”- WebMD Medical Reference from eMedicineHealth
This website does not replace physician care. For medical advice, diagnosis, and treatment please contact a physician. Personal data collected through this website is not distributed or made available to the public.
Starting with 10 minutes of exercise a day can lower your overall feelings of stress. The hormones produced by your exercise session can help you better deal with stressful situations, even long after you have finished exercising.
For some, the culprit is obvious—they’ll eat a peanut butter cookie, for example, and immediately break out in a rash. For others, it’s not so cut and dry; symptoms can take several hours to develop. Either way, make an appointment with your doctor if you suspect you have a food allergy. Dr. Jaliman says you’ll likely be put on an elimination diet where you reintroduce one potentially triggering food every week. “Let’s say you’re not eating any of the hives foods and then you add back shellfish and you get the hives again. Then you can pretty much figure it out,” Dr. Jaliman says. After you determine the culprit, nix it from your diet to prevent mild symptoms from becoming chronic. Dr. Jaliman says you’ll likely be prescribed an EpiPen—if you accidentally ingest a trigger food, you could get hives in your throat, which can be dangerous. 
You may have a sensitivity to detergent, soap, clothing, perfumes and/or foods. Have you changed any daily habit in the last 16 months? New detergent or soap? Try using only natural detergents and soaps for a while to see if it helps. Wear only cotton or linen clothing. Keep a diet diary, writing down all the foods you eat — see if the itching gets worse after you eat certain foods.
Urticaria that is caused by an allergy is usually due to an allergy to foods, spices, food additives or preservatives, insect stings or drugs. The most common foods that cause urticaria are seafood, berries, nuts, eggs and chocolates (but almost every food has been implicated), and the most common additives are preservatives, nitrates and colourants such as tartrazine. Drugs commonly implicated are over-the-counter medications, antibiotics, aspirin, medicines containing tartrazine, birth control pills and medication for colds. Insect bites, worm infestation and infections also commonly result in urticaria. Contact with dogs, cats, pollens, plants, and blood transfusions may also cause urticaria. Auto immune mechanisms may also be involved (this is where the body becomes ‘allergic’ to itself!)
The most common causes of hives are an allergic reaction to certain medications such as antibiotics or codeine ingestion of foods like shellfish chocolate or berries or contact with pollen and cat dander.
“The patient who presents with relatively minor dermatological symptoms and a seemingly disproportionate amount of distress about these symptoms is telling you something,” she says. “They are telling you that they are experiencing significant distress but may not have the capacity to recognize the psychological contribution to their suffering.”
Clinical Context:  Hydroxychloroquine is the preferred antimalarial agent because of its low toxicity and high effectiveness profile. It is usually well tolerated if carefully monitored by the prescribing physician. Therapy is required for 4-8 weeks before evaluating effectiveness.
The band also won five prestigious Swedish Grammis for Tyrannosaurus Hives at the 23rd annual Swedish Grammis Awards, presented on 7 February 2005 for “Artist of the Year”; “Rock Group of the Year”; “Album of the Year”; “Producer of the Year” (with collaborator, Pelle Gunnerfeldt); and “Walk Idiot Walk” took home the MTV “Best Music Video” prize.[7][8]
In addition, it is best to avoid tight fitting clothing over the areas affected by the stress hives, and to avoid hot or cold baths and showers as this can cause further skin irritations and cause hives from stress to spread. Please see our how to get rid of hives page for tips on how to alleviate your symptoms until your order of OxyHives arrives.

“itchy hives all over body _hives around eyes”

Pityriasis rosea typically fades without treatment in six to eight weeks. During this time, you can use an OTC anti-itch medication, like diphenhydramine (Benadryl) or cetirizine (Zyrtec) to ease your symptoms.
The symptoms of hives include itching in most cases, swelling of the area, red welts that look much like a mosquito bite. If you have any of these symptoms, you may have hives. Most doctors when presented with hives, will try to test to find out the allergen that is responsible for the case. If the allergen simply cannot be found, such as in cold hives, only the symptoms are treated. Many doctors will give antihistamines because histamines are released into the system and this is what causes hives to form, but these commonly given antihistamines and corticosteroids only treat symptoms, not the causes. If you or your child has a life threatening case that causes constricted breathing, epinephrine is commonly given on the spot.
37. Sabroe RA, Fiebiger E, Francis DM, et al. Classification of anti-FcepsilonRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity. J Allergy Clin Immunol. 2002;110:492–9. [PubMed]
Acute hives can appear at any age, but they are most commonly seen in young adults. The rash has very itchy red areas with white raised central circles that resemble mosquito bites. If the welts grow very large, spreading and joining together or swelling downward deep into body tissue, then they are known as giant hives or angioedema. Angioedema is painful and unsightly, but it is not as itchy. With angioedema the eruptions become large enough to cause swelling of the eyelids, tongue, mouth, hands or feet. In severe cases, hives can be accompanied by other symptoms such as difficulty in breathing, difficulty swallowing, digestive upsets and fever. Hives can occur internally to produce swelling of internal organs. .
Leukotrienes are released from mast cells along with histamine. The medications, montelukast and zafirlukast block leukotriene receptors and can be used as add on treatment or in isolation for patients with CU. It is important to note that these medications may be more beneficial for patients with NSAID induced CU.[42][43]
Chronic hives don’t last forever. Most people have them for 1 to 5 years. For a small number of people, it can last longer. There’s no known cure, but medicines and lifestyle changes can help you feel better.
The cause of most cases of urticarial vasculitis is unknown. It may be associated with a number of diseases, especially systemic lupus erythematosus, rheumatoid arthritis and Sjögren’s syndrome. Some cancers, including leukemias, colon and pancreatic, and infections like Hepatitis B and C can cause this form of vasculitis. So can some drugs, including antibiotics, ACE inhibitors used for treating high blood pressure, and certain diuretics.
Physical Urticaria (Inducible Urticaria) in its most simple form usually presents as linear scratches or Dermatographism.   Physical Urticaria is triggered by common physical stimuli such as heat, cold, sun exposure, vibration, exercise, deep pressure and even occasionally from water exposure (Aquagenic). The weals occur within minutes of the stimulus and disappear rapidly within an hour or two. Just to complicate matters, Physical Urticaria may occur together with Chronic Idiopathic Urticaria.  While Contact Urticaria an immediate allergy occuring after skin contact with fresh foods (potato, shellfish), pet saliva or latex and settles within a few hours.
Could you be allergic to your own sweat? Yes, says Dr. Anand. Although the cause of hives triggered by exercise is sometimes thought to be an increase of body heat, what actually triggers hives when you work out is sweat. Does that mean you should skip exercise if you have chronic hives? Not necessarily. Talk to your doctor if you suspect this may be one of your triggers — he or she may recommend taking a dose of antihistamine just before you exercise to help prevent a flare-up.
The word “rash” means an outbreak of red bumps on the body. The way people use this term, “a rash” can refer to many skin conditions. The most common of these are scaly patches of skin and red, itchy bumps or patches all over the place.
Urticaria may be classified on the basis of underlying aetiology (see Table 1) or by a clinical classification. In most cases of chronic urticaria it will not be possible to identify the underlying cause, i.e. the rash is idiopathic; however, when seeing a patient, it is helpful to use a clinical classification, as this guides history-taking and ensures that in any one individual all possible triggers for the urticaria are identified. In some patients several factors may cause/worsen the rash.
Stephen C Dreskin, MD, PhD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Association for the Advancement of Science, American Association of Immunologists, American College of Allergy, Asthma and Immunology, Clinical Immunology Society, and Joint Council of Allergy, Asthma and Immunology
Hives are patches of puffy, red, itchy or inflamed skin also known as urticaria, and they can be caused or worsened by significant stress in your life. In fact, stress is one of the most common causes of acute hives (hives that last less than six weeks), along with infectious causes and allergies. Stress has also been known to worsen chronic hives (hives that last more than six weeks), even when the chronic hives are primarily due to another cause.
Hives (urticaria) are raised, red spots on the skin that often itch. Hives are usually indicative of an allergic reaction. Hives are a common reaction in people who have allergies. A number of substances can trigger an outbreak of hives, including foods, medications, pollen, animal dander, or insect bites.

“treatment for cholinergic urticaria causes of hives in adults”

Jump up ^ Langan, EA; Nie, Z; Rhodes, LE (Sep 2010). “Melanotropic peptides: more than just ‘Barbie drugs’ and ‘sun-tan jabs’?”. The British Journal of Dermatology. 163 (3): 451–5. doi:10.1111/j.1365-2133.2010.09891.x. PMID 20545686.
The Asthma and Allergy Foundation of America (AAFA), a not-for-profit organization founded in 1953, is the leading patient organization for people with asthma and allergies, and the oldest asthma and allergy patient group in the world.
Hives, also known as urticaria, are a type of skin rash that are the result of an allergic reaction to a substance, called an allergen, in the environment. Although the cause of hives is not always known, they are often a response to the body releasing histamines, which it does when you have an allergic reaction to food, medicine, or other allergens. Histamine is also sometimes the body’s response to infections, stress, sunlight, and changes in temperature. Hives typically manifest as small, swollen, itchy, red areas on the skin that may occur singularly or in clusters. Left untreated, hives usually fade within a few hours, but new ones may appear in their place.[1] If you want to try to cure your hives at home, there are many different natural remedies to treat your hives.
Here’s an additional reason to brush, floss, and see your dentist regularly: In a study published in April 2013 in the journal Advances in Dermatology and Allergology, researchers found that tooth decay and several other infections can play a significant role in the development of chronic hives. Bacterial infections (such as urinary tract infections and strep throat) and viral infections (such as hepatitis and norovirus, a common cause of stomach “flu”) were also found to be triggers of chronic hives.
Categories: The HivesEpitaph Records artistsGarage punk groupsSwedish indie rock groupsSwedish punk rock groupsMusical quintetsBurning Heart Records artistsSwedish rock music groupsMusical groups established in 1989
Avoidance of known triggering factors is important, and patients with urticaria should be discouraged from scratching or irritating the skin when active lesions are present. Pressure urticaria may worsen the intensity of the rash; therefore, avoiding tight-fitting clothes may be helpful.
Initially it is helpful to explain to patients what urticaria is and that very often it is not due to ‘an allergy’. They may be reassured that in nearly all cases there is no serious underlying medical problem causing the rash; that safe, effective treatments are available and that the long-term prognosis is usually good. A patient information leaflet, such as that available from the British Association of Dermatologists [48], is helpful.
Skin biopsy may be performed to confirm urticarial vasculitis. Microscopic findings of early lesions include a neutrophil leukocytoclastic vasculitis, in which there is damage to small vessels in the middle layers of the skin (dermis). In later lesions, a lymphocytic vasculitis may be seen.
We classify Urticaria into Acute Urticaria when the rash duration is under 6 weeks and Chronic Urticaria when it persists for over 6 weeks. Physical Urticaria is due to an external physical trigger such as heat, cold, pressure or exercise (also called Inducible Urticaria). While Urticarial Vasculitis is a rare condition associated with underlying auto-immune connective tissue diseases which requires specialist referral.
Urticarial vasculitis carries a good prognosis, with most occurrences resolving in months to years. Urticarial vasculitis associated with hypocomplementemia is associated with a greater incidence of coexisting disease (ie, angioedema, connective-tissue disease [primarily SLE], chronic obstructive pulmonary disease).[10, 11] Mortality is rare. Some cohorts have demonstrated systemic involvement in roughly half of the patients, including musculoskeletal and ocular complications.[12]
Aloe vera gel can also be applied over the affected area to reduce inflammation. Aloe vera gel is know to have a cooling effect and this will help provide relief, especially if you have the urge to scratch the inflamed area.
An allergic reaction can cause hives, as can temperature extremes, stress, infections, or illnesses. In some cases, hives are accompanied by angioedema, a condition that can cause swelling around the eyes, lips, hands, feet, or throat. Very rarely, hives and angioedema are associated with an allergic reaction that involves the whole body or anaphylactic shock.
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In chronic cases, a physician may check various blood and urine tests, and other procedures such as X-rays to look for other causes. If a physical urticaria is suspected, special tests to mimic the physical stimulus may be performed, such as placing an ice cube on the skin to cause a hive to form in people with cold urticaria.
Chronic urticaria is usually treated with antihistamine medication. Antihistamines are commonly available as over-the-counter medications. They can often be effective in stopping itch and preventing future outbreaks of urticaria.  Medication usually needs to be continued for many weeks and long term treatment may be required in some cases to keep the condition under control.
If these agents fail, colchicine, hydroxychloroquine, or dapsone may be effective. If all other treatment modalities have failed or if the patient has systemic involvement, consider initiating treatment with glucocorticoids. If the patient requires long-term treatment with corticosteroids, consider every-other-day dosing of the steroid or the addition of azathioprine as a steroid-reducing agent. Response to newer agents, including mycophenolate mofetil[20, 21] and rituximab, has been reported in the literature. Rituximab-based treatment can provide higher response rates compared with corticosteroids and conventional immunosuppressive agents, which supports its use in relapsing, refractory, or severe disease.[12]
Research shows that stress can play a major role in many physical and mental illnesses, including chronic idiopathic hives. “Stress can bring on and exacerbate chronic hives,” says Anand. “It’s not uncommon to see chronic idiopathic hives developing following a stressful period of time.” In several studies, people with chronic hives have been found to have higher levels of stress. Researchers have also found a link between post-traumatic stress disorder and hives. To lower stress, try relaxation techniques — for example, mindfulness meditation, which was found to lower the stress hormone cortisol in a study published in 2013 in the journal Health Psychology.
Chronic urticaria (ordinary urticaria)[32] is defined as the presence of evanescent wheals which persist for greater than six weeks.[31] Some of the more severe chronic cases have lasted more than 20 years. A survey indicated chronic urticaria lasted a year or more in more than 50% of sufferers and 20 years or more in 20% of them.[33]
Solar urticaria is a rare disorder in which urticaria develops on areas of the body which are exposed to sunlight. Itching and urticaria may develop within a few minutes and may progress to angioedema. The symptoms usually resolve in a few hours. (Polymorphic light eruption may also cause an itchy rash on sun-exposed skin, but this rash is papular or eczematous; usually starts 6–8 h after sun exposure and lasts for several days.) Very rarely, patients may develop ‘aquagenic’ urticaria where their skin has been in contact with water (irrespective of its temperature) or urticaria in response to vibration.
This chronic condition can also make your skin red and itchy. Although it’s most common in children, it can occur at any age. It generally starts as small, raised bumps. These bumps may leak fluid if scratched. The rash can form thickened areas of skin over a larger area, called plaques.
Individuals who have urticaria due to aspirin may need to avoid foods that contain high levels of salicylates. As well as this, antihistamines are the mainstay of drug treatment for urticaria and angioedema. They may be taken just when required or regularly to prevent episodes occurring in chronic spontaneous urticaria.
Jump up ^ PhD, [edited by] Kathryn L. McCance, RN, PhD, Sue E. Huether, RN, PhD ; section editors, Valentina L. Brashers, MD, Neal S. Rote, (2014). Pathophysiology : the biologic basis for disease in adults and children (Seventh edition. ed.). Elsevier – Health Sciences Division. ISBN 9780323088541.
How long do hives last? Mild hives can appear suddenly and be completely gone a few minutes later. Other times, hives can last for hours and even several weeks to months. Acute episodes of urticaria last for six weeks or less. Hives that last for six weeks or less are acute hives. Those that remain for more than six weeks are chronic hives. It’s nice to know that the majority of hives cases don’t last longer than 24 hours. (4)
If you have a severe episode of hives then you may be referred to a specialist. Skin specialists (called dermatologists) or allergy specialists (called immunologists) may be able to help. In particular, if angio-oedema or anaphylaxis occurred at the same time, you would be referred or admitted to hospital. This is to reverse the reaction quickly. It is also to confirm the diagnosis and, where possible, to identify a cause. For example, if a nut allergy is suspected to have caused a severe episode then this can confirmed by tests. You may then be given advice on how to avoid the cause and on what to do if it should occur again.
Urticaria, commonly referred to as hives, is the most frequent dermatologic disorder seen in the emergency department (ED). It appears as raised, well-circumscribed areas of erythema and edema involving the dermis and epidermis that are very pruritic. Urticaria may be acute (lasting <6 wk) or chronic (lasting >6 wk). A large variety of urticaria variants exist, including acute immunoglobulin E (IgE)–mediated urticaria, chemical-induced urticaria (non-IgE-mediated), autoimmune urticaria, cholinergic urticaria, cold urticaria, mastocytosis, periodic fever syndromes including Muckle-Wells syndrome, and many others. [2, 10] While acute urticaria is generally related to an exogenous allergen or acute infection, chronic urticaria is more likely to be associated with autoimmunity. [8, 11, 12]
Blanchable, raised, palpable wheals, which can be linear, annular (circular), or arcuate (serpiginous); can occur on any skin area; are usually transient and migratory; and may coalesce rapidly to form large areas of erythematous, raised lesions that blanch with pressure
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
Hives can also develop as a result of sun or cold exposure, infections, excessive perspiration, and emotional stress. The reason why stress seems to precipitate an outbreak of hives in many people not completely understood but is likely related to the known effects of stress on the immune system. In many cases, the cause of hives in a given individual cannot be identified.
Bluestein HM, Hoover TA, Banerji AS, Camargo CA Jr, Reshef A, Herscu P. Angiotensin-converting enzyme inhibitor-induced angioedema in a community hospital emergency department. Ann Allergy Asthma Immunol. 2009 Dec. 103(6):502-7. [Medline].
Yang, H. Y., Sun, C. C., Wu, Y. C, & Wang, J. D. (2005, April). Stress, insomnia, and chronic idiopathic urticaria, a case-control study. Journal of the Formosan Medical Association,104(4):254-63. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/15909063
Urticaria affects almost 20 percent of the population but the majority of the time, the cause is unknown (idiopathic). Even so, it is a good idea to try to find the trigger so you can possibly avoid it in the future.
Urticarial vasculitis is a condition characterized by inflammation of the small blood vessels in the skin. Signs and symptoms include an itching and burning sensation in the affected skin. Lesions (wheals) caused by urticarial vasculitis may also leave behind a bruise.
What causes hives? Hives are typically caused by an allergic reaction. The allergy can be to a food or medication. When your body is allergic to something, it can release chemicals that make your skin develop hives. An infection or emotional stress can also cause hives.
Chronic urticaria and angioedema can affect other internal organs such as the lungs, muscles, and gastrointestinal tract. Symptoms include muscle soreness, shortness of breath, vomiting, and diarrhea.

“urticaria vasculitis -tricardia”

Insect venoms, animal danders and/or saliva, penicillin, protease enzymes in biological detergents [6] and latex proteins are other common causes of IgE-mediated urticaria, which again are often identified by the patient. Patients who are latex-protein allergic may also react to a wide variety of foods [7] (Table 2) because of cross-reactivity between the latex protein antigens and food antigens or, if they are highly sensitized, they may develop symptoms after eating foodstuffs which have been handled by workers wearing latex gloves [8].
Autoimmune urticaria (in the European guidelines this would come under the chronic spontaneous urticaria subtype above[4]). This may account for half of all cases of chronic urticaria in adults and older children. There may be an association with other autoimmune conditions.
Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler’s educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
The rash may be triggered by an allergy, or by another factor such as heat or exercise. In most cases the rash lasts 24-48 hours and is not serious. You may not require any treatment; however, medicines called antihistamines can ease the symptoms until the rash clears.
Stress hives develop due to chronic stress or tension in your life, and appear as red, raised and swollen areas on the skin that seem to suddenly appear. Stress hives, which are also known as a stress rash or as stress bumps, are often incredibly itchy, and some people report having a burning or stinging sensation wherever they appear. Stress induced hives will go away by themselves when you have successfully released ALL the stress from your body or taken the hives treamtment OxyHives, which will eliminate your symptoms.
There is just not enough evidence to support using antihistamines and playing roulette with your patient’s health,” he said, noting that the degree of disability, both socially and occupationally, that accompanies chronic urticaria is on par with that of a patient awaiting triple coronary bypass.
Milder cases of Urticarial Vasculitis may simply be treated with antihistamines and NSAIDs such as Ibuprofen. Corticosteroids such as Prednisolone might be used for more persistent cases. However for the more severe forms of Urticarial Vasculitis, steroids such as Prednisolone are usually prescribed to reduce inflammation as well as immunosuppressants such as Azathioprine, Cyclophosphamide or Mycophenolate Mofetil (CellCept).
Research shows that up to 50% of people with CIU continue to have hives after treatment with antihistamines. Omalizumab, which is injected under the skin, has been shown to relieve the itch and clear hives in some people with CIU. In one research study, 36% of patients treated with omalizumab reported no itch and no hives after treatment.
Bluestein HM, Hoover TA, Banerji AS, Camargo CA Jr, Reshef A, Herscu P. Angiotensin-converting enzyme inhibitor-induced angioedema in a community hospital emergency department. Ann Allergy Asthma Immunol. 2009 Dec. 103(6):502-7. [Medline].
Treatment guidelines for the management of chronic hives have been published.[37][38] According to the 2014 American practice parameters, treatment involves a step wise approach. Step 1 consists of second generation, H1 receptor blocking antihistamines. Systemic glucocorticoids can also be used for episodes of severe disease but should not be used for long term due to their long list of side effects. Step 2 consists of increasing the dose of the current antihistamine, adding other antihistamines, or adding a leukotriene receptor antagonist such as montelukast. Step 3 consists of adding or replacing the current treatment with hydroxyzine or doxepin. If the individual doesn’t respond to steps 1–3 then they are considered to have refractory symptoms. At this point, anti-inflammatory medications (dapsone, sulfasalazine), immunosuppressants (cyclosporin, sirolimus) or other medications like omalizumab can be used. These options are explained in more detail below.
No. Seriously, stress is a mental state. And we treat mental problems with mind treatment, not with supplements. This advice, unfortunately, fails to and explain the real cause of your stress problem.

“multivariable grapher home remedies for urticaria”

In most cases urticarial vasculitis is idiopathic, but it may be associated with connective tissue diseases such as SLE or Sjögren’s syndrome; infections such as hepatitis B and C, Lyme disease and infectious mononucleosis; treatment with drugs, including ACEI, cimetidine, diltiazem, penicillins, sulphonamides and thiazides; and lymphoproliferative diseases such as mixed cryoglobulinaemia and IgM gammopathy. A specific syndrome of urticarial vasculitis and IgM gammopathy with fever, bone pain and arthralgia or arthritis –‘Schnitzler’s syndrome’ – was first described in 1972 [76,77].
Urticaria and angioedema often occur at different times or together in the same person. They occur in about 15 per cent of the population at some time or other in their lives, with women more commonly affected  than men.
The cause of chronic hives can rarely be determined.[28] In some cases regular extensive allergy testing over a long period of time is requested in hopes of getting new insight.[29][30] No evidence shows regular allergy testing results in identification of a problem or relief for people with chronic hives.[29][30] Regular allergy testing for people with chronic hives is not recommended.[28]
It is estimated that 20% of all people will develop urticaria at some point in their lives. Hives are more common in women than in men. One hallmark of hives are their tendency to change size rapidly and to move around, disappearing in one place and reappearing in other places, often in a matter of hours. An individual hive usually lasts no longer than 24 hours. An outbreak that looks impressive, even alarming, first thing in the morning can be completely gone by noon, only to be back in full force later in the day. Very few skin diseases occur and then resolve so rapidly. Therefore, even if you have no evidence of hives to show the doctor when you get to the office for examination, the diagnosis can be established based upon the accurate recounting of your symptoms and signs. Because hives fluctuate so much and so fast, it is helpful to bring along a photograph of what the outbreak looked like at its most severe point.
If you have a bad allergic reaction, like shortness of breath, talk to your doctor about a prescription medicine called an “auto-injector.” This medicine stops the allergic reaction when you inject it into your thigh. Follow your doctor’s advice on how to use this medicine.
Chronic hives can lead to severe discomfort, distress, and possibly depression. Stress, too, can aggravate hives, creating a vicious cycle. Patients who experience symptoms of depression should speak to a doctor.
Diseases such as systemic lupus erythematosus (SLE) and Sjögren’s syndrome may be associated with chronic urticaria, a cryoglobulin-related urticaria or urticarial vasculitis (see below). There is an increased incidence of autoimmune thyroid disease in patients with chronic urticaria, particularly those with histamine-releasing autoantibodies –‘autoimmune urticaria’ (see below) [29,30]. Patients are usually clinically euthyroid, but both hypothyroidism and hyperthyroidism [31] may present with urticaria. Although there are case reports of urticaria associated with malignancy, a study of more than 1000 patients showed no association between chronic urticaria and malignancy [32]. In contrast, urticarial vasculitis may sometimes occur in patients with lymphoproliferative disease (see below).
Because blood and allergy tests exist to confirm hives at the doctor’s office, and antihistamines are readily available over the counter, determining the diagnosis and appropriate treatment might seem easy. However, since many of these disorders show the same symptoms and have different treatment methods, it’s important to be aware of the similarities and differences between them. So, read on to learn about five common skin disorders that may look and a lot like hives.
Cold urticaria is usually idiopathic, but it may occur in patients with cold-dependent antibodies, such as cryoglobulins or cold agglutinins [15] and there is a very rare familial form of cold-induced urticaria which is dominantly inherited [16]. Patients develop itching, erythema and urticaria affecting that part of the body which has been exposed to cold. Symptoms may worsen as the exposed area is warmed. Total immersion in cold water can cause severe symptoms with hypotension and patients should be warned that swimming in cold water can be dangerous. Local heat-induced urticaria is rare [17]. Some unfortunate patients may develop urticaria on exposure to both heat and cold [18]. Generalized heat-induced urticaria or ‘cholinergic’ urticaria is caused by exercise, sweating and hot showers or baths. The term ‘cholinergic’ is used because sweat glands are innervated by cholinergic nerve fibres. The urticarial lesions are often small and intensely itchy. Very severe cholinergic urticaria may cause hypotension and therefore there may be some overlap with the clinical syndrome of exercise-induced anaphylaxis [19,20].
Acute urticaria can be divided into two general types, depending on the rate at which hive formation occurs and the length of time it is evident. One type produces lesions that last 1-2 hours and is typically encountered in physically induced hives. The inciting stimulus is present only briefly, and there is prompt mast cell degranulation. Biopsy of such lesions reveals little or no cellular infiltrate. The second type produces a prominent cellular infiltrate, and individual lesions can last as long as 36 hours. This type is encountered with food or drug reactions, delayed pressure urticaria, chronic spontaneous urticaria, and urticarial vasculitis  (click for picture).

“corticare pictures of urticarial vasculitis”

Urticaria occurs when certain substances such as histamine are released from specific cells in the skin. This process is usually triggered by various immunologic mechanisms, most commonly involving the presence of circulating “IgE” antibodies, although other pathways may also be involved.
To know exactly what kind of hives one has, or to learn more about research into the immune basis of hives or about rarer forms of this condition, consult a physician. It is important, however, to keep in mind that most cases of urticaria are annoying, not serious, and almost always temporary.
The skin is the body’s largest organ, so it’s not uncommon for a variety of other medical conditions to affect it and this may result in hives. For instance, people with cancers like lymphoma may be prone to hives, as are those dealing with carcinomas (skin cancer).​
Urticaria is characterized by itchy bumps or areas of raised skin that are light red in color and cause intense itching. This condition is commonly known as hives and while it is most commonly caused by an allergic reaction it can also have non-allergic causes. Urticaria is classified as either acute or chronic and this is dependant on how long the outbreak lasts. Outbreaks that last for less than 6 weeks are referred to as acute urticaria cases while those that last for longer periods are termed as chronic. Acute urticaria is generally the result of an allergic reaction while chronic urticaria often has autoimmune causes. An acute viral infection can also be a cause of acute urticaria. Hives are also known to be caused by local pressure, friction, extremes of temperature, and sunlight.
Mastocytosis is a disease in which there is mast cell hyperplasia affecting the skin, gastrointestinal tract, bone marrow, liver, spleen and lymph nodes. Clinical features include urticaria, pruritus, flushing, nausea, vomiting, abdominal pain, diarrhoea and headache. Patients may be prone to severe anaphylactoid reactions after exposure to certain medications [79] and severe anaphylactic reactions after exposure to antigens to which they are sensitized, such as insect venom [80], because of the increased tissue load of mast cells. Mastocytosis is classified into cutaneous and systemic variants and urticaria pigmentosa is the most common form of cutaneous mastocytosis, occurring in approximately 85% of children and 95% of adults in whom mastocytosis is limited to the skin. Systemic mastocytosis varies from an indolent condition, where there is no associated haematological disease, to an aggressive mast cell leukaemia. The lesions of urticaria pigmentosa are variable in colour, macular or maculopapular and are usually symmetrical in distribution, with sparing of the extremities and face. The diagnosis of urticaria pigmentosa is made by skin biopsy, which shows a significant increase in dermal mast cells [81]. Patients have symptoms of pruritus and dermographism and pressure on affected skin causes erythema and urtication –‘Darier’s sign’. Children usually present before the age of 2 years and urticaria pigmentosa may be present at birth. They tend to have fewer, larger skin lesions than adults and they may also develop bullae, which do not occur in adults. Treatment is with H1 and H2 anti-histamines and ketotifen [82] (an anti-histamine with mast cell-stabilizing properties), methoxsalen with long-wave ultraviolet radiation (psoralen plus ultraviolet A,) [83] and topical steroids [84] may all be used to alleviate urticaria and pruritus. It is rare for children to develop systemic mastocytosis and urticaria pigmentosa resolves completely in about 50% of children. In contrast, urticaria pigmentosa in adults usually persists and about 50% of patients may go on to develop systemic mastocytosis. The prognosis in adults is, therefore, highly variable.
Urticarial Vasculitis is a form of cutaneous vasculitis characterised by inflammation of the small blood vessels. Urticarial Vasculitis can be classified into three subtypes. All are defined by a measure of the “complement” levels in the blood. The complement system is a set of proteins that contribute to and amplify immune responses. They play a role in some, but not all, autoimmune disorders including some forms of Urticarial Vasculitis.
In acute (short-lived) hives, the weals may come and go for a few days or weeks. Rarely, they persist for more than six weeks. Chronic hives is much less common. The weals come and go for months or even years. 
Histamine is the ligand for 2 membrane-bound receptors, the H1 and H2 receptors, which are present on many cell types. The activation of the H1 histamine receptors on endothelial and smooth muscle cells leads to increased capillary permeability. The activation of the H2 histamine receptors leads to arteriolar and venule vasodilation. [3, 4, 5] This process is caused by several mechanisms as follows:
Acute urticaria may be, in a short time, associated with life-threatening angioedema and/or anaphylactic shock, although it usually presents as rapid-onset shock without urticaria or angioedema. (See Emergency Care and Complications.)
If your hives are uncomfortable or disrupting your life, consider seeing an allergist or physician to determine the underlying cause, especially if you have never had hives before. In many cases, a doctor can prescribe or recommend an over-the-counter medication that can help relieve your symptoms or calm down your hives as they occur.
Stress hives suck, but they’re not the end of the world. If you have chronic urticaria, it’s a good sign that stress is really eating away at you and having a negative effect on your life. My goal with TSM is to help you manage stress and live a more enjoyable life. Don’t let stress control your life.
Skin examination should note the presence and distribution of urticarial lesions as well as any cutaneous ulceration, hyperpigmentation, small papules, or jaundice. Urticarial lesions usually appear as well-demarcated transient swellings involving the dermis. These swellings are typically red and vary in size from pinprick to covering wide areas. Some lesions can be very large. In other cases, smaller urticarial lesions may become confluent. However, skin lesions also may be absent at the time of the visit. Maneuvers to evoke physical urticaria can be done during the examination, including exposure to vibration (tuning fork), warmth (tuning fork held under warm water), cold (stethoscope or chilled tuning fork), water, or pressure (lightly scratching an unaffected area with a fingernail).
Anti-inflammation medications. Oral corticosteroids, such as prednisone, can help lessen swelling, redness and itching. are generally for short-term control of severe hives or angioedema because they can cause serious side effects if taken for a long time.
Although clinically distinctive, urticaria may be confused with a variety of other dermatologic diseases that can be similar in appearance and are pruritic, including atopic dermatitis (eczema), maculopapular drug eruptions, contact dermatitis, insect bites, erythema multiforme, pityriasis rosea, and others. Usually, however, the experienced clinician is able to distinguish these conditions from urticaria because of the lesions’ hallmark appearance (see the images below), a lack of epidermal change, the intense pruritus, the presence of an advancing edge and a receding edge, the complete blanching of the lesions with pressure, and are the transient nature of the lesions. [1] (See Clinical Presentation.)
Allergic hives and angioedema form when, in response to histamine, blood plasma leaks out of small blood vessels in the skin. Histamine is a chemical released from specialized cells along the skin’s blood vessels.
Antihistamine tablets can ease symptoms. Antihistamines block the action of histamine which is one of the chemicals involved in causing hives. You can get antihistamines on prescription. You can also buy them without a prescription from pharmacies. There are several types. The pharmacist will advise. The ones most often used for hives are:
Dermographism literally means skin writing. Scratching the skin will produce a raised mark and redden the surrounding skin. It is easy to test. Simply use a moderately sharp object, such as a fingernail or a key, and run it over the skin. If a recognizable patter is used in testing, such as a name or the game of X’s and O’s, it is a form of physical urticaria which is easily identified.
Acute and chronic urticaria can result in severely impaired quality of life from pruritus and associated sleeplessness, as well as anxiety and depression. The depression can be severe enough to lead to suicide in rare cases. Additionally, many of the diseases associated with chronic urticaria may cause significant morbidity and mortality.
There has been a high incidence of autoantibody to thyroid glands reported among those with anti-Fc-receptor antibodies and it is suggested that yearly thyroid testing be done by the primary care physician.
The skin reaction usually becomes evident soon after the scratching, and disappears within 30 minutes. Dermatographism is the most common form of a subset of chronic hives, acknowledged as “physical hives”.[citation needed]
61. Shahar E, Bergman R, Guttman-Yassky E, Pollack S. Treatment of severe chronic idiopathic urticaria with oral mycophenolate mofetil in patients not responding to antihistamines and/or corticosteroids. Int J Dermatol. 2006;45:1224–7. [PubMed]
Intense emotional responses can trigger a hives outbreak. For those with chronic hives, or hives that persist for more than six weeks at a time, stress and anger can heat up the body and cause it to release histamine.
If the cause of the urticaria is known or suspected, such as a food or medication, avoidance of this trigger may resolve the symptoms. In cases of chronic idiopathic urticaria, triggers such as acute infections of any kind (such as the common cold), stress, and use of non-steroidal anti-inflammatory medications (aspirin and ibuprofen, for example), may trigger the symptoms.
An easy natural cure for hives is to soak a ball of cotton wool in milk of magnesia and apply the lotion all over the rash. Milk of magnesia has alkaline properties that help in soothing the skin and reducing the pain as well. In place of milk of magnesia, you can apply vitamin E oil for the same results. Repeat this process at least twice to three times a day.
Dermatographism: This is the ability to ‘write on the skin’. If the skin is stroked firmly with a solid object a characteristic wheal and flare reaction occurs. You would be able to read what was “written” on the skin for a prolonged period of time.
If you’re wondering how to get rid of your hives at home, then we can help. We’ve created a special Top 10 Best Ways To Get Rid Of Your Hives list that is going to be exactly what you need to determine what is causing your hives and how to stop them quickly and at home with natural remedies.
Use nettles. Nettles have been traditionally used to treat hives because it is natural antihistamine. You can make nettles into tea, eat it, or take it as a supplement. To make a cup of nettles tea, take 1 tsp of the dried herb and add it to a cup of hot water. Let it steep and allow it to cool. Soak a cotton towel with the nettles tea, wring out the excess tea, and place the damp towel over the hives. Use as often as needed.
Other natural remedies for hives include applying aloe vera gel on the affected skin or making a paste with oatmeal and cornstarch and coating the rash with it. Keep this paste on for thirty minutes before washing it off with water. Lotions containing aloe vera as an ingredient are also effective.
Dermatographic urticaria (also known as dermatographism or “skin writing”) is marked by the appearance of weals or welts on the skin as a result of scratching or firm stroking of the skin. Seen in 4–5% of the population, it is one of the most common types of urticaria,[11] in which the skin becomes raised and inflamed when stroked, scratched, rubbed, and sometimes even slapped.[12]